What Is Sickle Cell Disease
Sickle Cell Disease is what a group of inherited red blood cell disorders is called. Oxygen-transporting red blood cells are typically round, and they flow through small blood vessels in order to deliver oxygen all over your body. SCD occurs when your blood develops an abnormal shape that makes your red blood cells become hard and sticky and resembles a C-shaped sickle. The sickle cell disease typically reduces the red blood cells, which leads to a shortage of red cells. Furthermore, when sickle cells travel through small blood vessels, they clot the blood and decrease the flow. This may cause pain or other serious complications such as pneumonia, acute chest syndrome, and stroke.
Signs and symptoms of sickle cell anemia usually appear around 6 months of age. They vary from person to person and may change over time. Signs and symptoms can include:
Anemia. Sickle cells break down easily, and rapidly die. Red blood cells generally last about 120 days before they need to be replaced, but sickle cells usually die in 10 to 20 days, resulting in a deficiency of red blood cells (anemia). Without enough red blood cells, the body can’t get enough oxygen and this causes fatigue.
Episodes of pain. Periodic episodes of extreme pain, called pain crises, are a major symptom of sickle-cell anemia. Pain begins as a result of sickle-shaped red blood cells blocking blood flow through blood vessels to your chest, abdomen, and joints.
The intensity of a pain crisis may vary based on how long it lasts. Someone might have one serious pain crises a year, while someone else may have 10 or even 20 in a year’s span. A painful condition may require hospitalization.
Some adolescents and adults with sickle cell anemia also have chronic pain, which can result from bone and joint damage, ulcers, and other causes.
Swelling of hands and feet. Sickle-shaped red blood cells impede the movement of blood in the hands and feet, causing the swelling.
Frequent infections. Sickle cells can damage the spleen, increasing vulnerability to infections. Children and infants with sickle cell anemia are ordinarily immunized and administer antibiotics to protect against communicable diseases, such as pneumonia.
Adolescents growth During puberty. The human body needs red blood cells to provide oxygen and nutrients necessary to accelerate growth or delay puberty. A lack of healthy red blood cells in children and infants can slow down their growth and delay puberty in teenagers. Visual damage. Tiny blood vessels that deliver the eyes could become clogged with sickle-shaped red blood cells.
Types of SCD
Following are the most common types of SCD:
People with this brand of blood disorder inherit two genes for SCD, one from their mother and the other from their father. This is commonly called sickle cell anemia and is easily the most severe form of the disease.
HbS beta thalassemia
HbSD, HbSE, and HbSO
Cause of SCD
Treatments & Complications
Sickle Cell Disease Study
Trial Search are looking to study & evaluate the safety and effectiveness of the investigational medication on improving anemia and reducing the number of annual sickle cell crises
Participants who qualify for the study will receive:
- All trial-related medical care, procedures, tests and trial medication.
- Compensation for time and travel.